Urine quantification is needed for assessing treatment response in Multiple Myeloma:
- Complete Response: negative IF for serum and urine
- Very good partial response: Detectable paraprotein (monoclonal protein) by IF in serum or urine but not on electrophoresis or decrease of more than 90% in serum paraprotein and urine paraprotein <100mg/24 h)
- Partial response: more than 50% reduction of serum paraprotein and over 90% reduction in urine paraprotein to <200mg/24hr
- Stable disease: no change after treatment
- Progressive disease: 25% increase of paraprotein compared to the lowest value observed (peak increase ≥ 5 g/L in the serum; peak increase≥ 200mg /24h in the urine).
