About CAPILLARYS 3 DBS
Capillary electrophoresis is a proven technology(1),(2),(3) for hemoglobin disorders screening and provides high quality results.
Sebia CAPILLARYS 3 DBS is the latest generation of instrument dedicated to newborn hemoglobin screening, offering a smooth workflow and excellent analytical features.
The CAPILLARYS 3 DBS instrument is an automated, multitasking capillary electrophoresis instrument using 12 capillaries for multiple simultaneous hands-free electrophoretic separations at high throughput.
The CAPILLARYS 3 DBS enables the analysis of samples from microplate wells and provides fully automated electrophoresis separation, from the dried blood spots on filter paper (Guthrie card) through to the final electrophoretic pattern: sample identification, sample dilution, sample incubation, capillary washing, sample injection into the capillaries, migration, detection, processing of the results, and transfer over the computer interface.
This instrument is an interesting alternative to commonly used technology such as IEF and HPLC for all the laboratories involved in newborn hemoglobin screening, bringing seamless sample traceability, high quality results, and high throughput while offering a reduced hands-on time.
Key benefits
High throughput instrument
Up to 70 samples/hour, enabling Newborn Screening laboratories to cope with their workload and deliver results to pathologists and clinicians quickly.
Full traceability
From sample punch to result, there is no interruption in the traceability chain, preventing transcription mistakes (e.g. errors from manually entering the sample ID into the analysis software).
High autonomy
8 full 96-well microplates could be analysed in a single run, without any reagent refill – This saves hands on time and lets the lab staff focus on important tasks.
Automatic Reagent Control
RFID tags for all reagents and Hb AF Control ensure a smooth and efficient reagent management, reducing user intervention.
Main characteristics
- Hb Neonat technique
Sample types: dried blood spot (3.2mm)
With 12 capillaries in parallel, the CAPILLARYS 3 DBS can process a large number of samples and can analyse up to eight 96-well microplates without reagent refill.
Throughput (tests/hour)*
CAPI 3 NEONAT Hb 70
* Using PHORESIS Software version 9.40 D
- Flexible positions for reagents allow for the optimisation of on-board reagent management
- RFID identification for all reagents (reagent type, lot number, expiration date, volume) allows comprehensive traceability throughout workflow
- Embedded user interface with a touch screen
- Automatic start-up and shutdown
- Visual alarms (with instrument notifications)
- A dedicated workstation pilots the instrument and manages results
- Uses barcoded microplates (supplied with the CAPI 3 NEONAT Hb reagent kit)
- Directly sampling from dried blood spots eluted from filter paper.
- Validated with the automated PerkinElmer™ puncher instruments (Panthera 9 and DBS models)
- Full sample traceability from sample card ID up to results, via barcoded microplates
- CAPILLARYS 3 DBS – P/N: 1244
Featured tests for CAPILLARYS 3 DBS
See all testsNewborn hemoglobin disorders screening
The perfect match for screening hemoglobin disorders in newborns.
Related resources
See all resourcesApr. 11, 2022 Dec. 21, 2024
IFCC Euromedlab 2021
Sebia booth: #121
Sebia Workshop: EduW22
CAPILLARYS 3 DBS – Introductory video
The perfect match for screening hemoglobin disorders in newborns
Jun. 27, 2022 Jun. 29, 2022
IFCC Worldlab 2022
Sebia booth: #72
Sebia Workshop: EduW25
May. 22, 2023 May. 24, 2023
IFCC Euromedlab /WorldLab 2023
Sebia booth: #21
Sebia Workshop: EduW15
Sebia receives U.S. FDA Clearance for the CAPILLARYS 3 DBS devices
The next generation instrument for screening hemoglobin disorders in newborns.
Scientific publications
See all publicationsNewborn Screening for Sickle Cell Disease and other Haemoglobinopathies – MDPI – 2019
This special Issue related to newborn screening for Sickle Cell disease and other hemoglobinopathies tried to cover the most widely faced challenges in the field of newborn screening for SCD.
Interested in CAPILLARYS 3 DBS?
(1) Hemoglobinopathies: Current: Practices for Screening, Confirmation and Follow-up – CDC – 2015 https://www.cdc.gov/ncbddd/sicklecell/documents/nbs_hemoglobinopathy-testing_122015.pdf
(2) NHS Sickle Cell and Thalassaemia Screening Programme- 2017 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/585126/NHS_SCT_Handbook_for_Newborn_Laboratories.pdf
(3) Newborn Screening for Sickle Cell Disease and Other Hemoglobinopathies: A Short Review on Classical Laboratory Methods—Isoelectric Focusing, HPLC, and Capillary Electrophoresis: https://www.mdpi.com/2409-515X/4/4/39
This section contains information intended for wide distribution and may therefore contain product details or information that is not available or valid in your country.
Please contact your local Sebia representative. Information intended for healthcare professionals.
Carefully read the instructions in the reagent package inserts and instrument manuals.