About CAPILLARYS 3 DBS
Capillary electrophoresis is a proven technology(1),(2),(3) screening for newborn hemoglobin disorders and provides high quality results.
Sebia CAPILLARYS 3 DBS is the latest generation of instrument dedicated to newborn hemoglobin screening, offering a smooth workflow and excellent analytical features.
The CAPILLARYS 3 DBS instrument is an automated, multitasking capillary electrophoresis instrument using 12 capillaries simultaneously for hands-free electrophoretic separation at high throughput.
The CAPILLARYS 3 DBS enables the analysis of samples from microplate wells and provides fully automated electrophoresis separation, from the dried blood spots on filter paper (Guthrie card) through to the final electrophoretic pattern: sample identification, sample dilution, sample incubation, capillary washing, sample injection into the capillaries, migration, detection, processing of the results, and data transmission to LIS.
This instrument is an innovative alternative to commonly used technology such as IEF and HPLC for all the laboratories involved in newborn hemoglobin screening, bringing seamless sample traceability, high quality results, and high throughput while offering a reduced hands-on time.
Key benefits
High throughput instrument
Up to 70 samples/hour, enabling Newborn Screening laboratories to efficiently manage their workload and deliver results to pathologists and clinicians quickly.
Full traceability
From sample punch to result, there is no interruption in the traceability chain, preventing transcription mistakes (e.g. errors from manually entering the sample ID into the analysis software).
Walkaway Automation
Load up to 8, 96-well microplates with continuous loading. This saves hands on time and lets the lab staff focus on important tasks.
Automatic Reagent Control
RFID tags for all reagents and Hb AF Control ensure a smooth and efficient reagent management, reducing user intervention.
Main Characteristics
- Hb Neonat technique
Sample types: dried blood spot (3.2mm)
With 12 capillaries in parallel, the CAPILLARYS 3 DBS can process a large number of samples and can analyse up to eight 96-well microplates without reagent refill.
Throughput (tests/hour)
CAPI 3 NEONAT Hb 70
- Flexible positions for reagents allow for the optimization of on-board reagent management
- RFID identification for all reagents (reagent type, lot number, expiration date, volume) allows comprehensive traceability throughout workflow
- Embedded user interface with a touch screen
- Automatic start-up and shutdown maintenance
- Visual alarms (with instrument notifications)
- A dedicated workstation pilots the instrument and manages results
- Uses barcoded microplates (supplied with the CAPI 3 NEONAT Hb reagent kit – P/N:2506)
- Directly samples from the elution of dried blood spots on filter paper.
- Validated with automated PerkinElmer™ puncher instruments Panthera 9 and DBS models.
- Barcoded microplates enable full sample traceability: from sample card ID through to final result
- CAPILLARYS 3 DBS – P/N: 1244
Featured tests for CAPILLARYS 3 DBS
See all testsNewborn Hemoglobin disorders screening
The perfect match for screening hemoglobin disorders in newborns.
Related resources
See all resourcesCAPILLARYS 3 DBS – Introductory video
The perfect match for screening hemoglobin disorders in newborns
Scientific publications
See all publicationsNewborn Screening for Sickle Cell Disease and other Haemoglobinopathies – MDPI – 2019
This special Issue related to newborn screening for Sickle Cell disease and other hemoglobinopathies tried to cover the most widely faced challenges in the field of newborn screening for SCD.
Interested in CAPILLARYS 3 DBS?
(1) Hemoglobinopathies: Current: Practices for Screening, Confirmation and Follow-up – CDC – 2015 https://www.cdc.gov/ncbddd/sicklecell/documents/nbs_hemoglobinopathy-testing_122015.pdf
(2) NHS Sickle Cell and Thalassaemia Screening Programme- 2017 https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/585126/NHS_SCT_Handbook_for_Newborn_Laboratories.pdf
(3) Newborn Screening for Sickle Cell Disease and Other Hemoglobinopathies: A Short Review on Classical Laboratory Methods—Isoelectric Focusing, HPLC, and Capillary Electrophoresis: https://www.mdpi.com/2409-515X/4/4/39
This section contains information intended for wide distribution and may therefore contain product details or information that is not available or valid in your country.
Please contact your local Sebia representative. Information intended for healthcare professionals.
Carefully read the instructions in the reagent package inserts and instrument manuals.