In 2014, the IMWG has added SLiM criteria (bone marrow plasmacytosis ≥ 60%, FLC i/u ≥100 along with the iFLC ≥ 100 mg/L, > 1 focal lesion on MRI) to the CRAB criteria (calcium elevation, renal insufficiency, anemia), as Myeloma Defining Events.
The iFLCr threshold (100) was defined because it was the cut-off associated with a 79% risk of progression to MM (Multiple Myeloma) or AL (AL amyloidosis) within 24 months, and with a specificity of 97% (Larsen JT et al, Leukemia, 2013).
In addition to this 100 ratio, the IMWG has then introduced the 20-20-20 system for assessing the Smoldering Multiple Myeloma (SMM) to MM progression. In that system, a patient with SMM receives 1 risk point for each of the following (M-spike>20 g/L, iFLCr>20 and BMPC>20%). This score is notably used for trial stratification and eligibility.
This publication indicates that the FLC cut-points can be used with Sebia ELISA FLC tests and allow for comparability within the field, to ensure an appropriate patient management.
En savoir plus sur nos technologies uniques
Cette rubrique contient des informations destinées à être diffusées largement et peut en conséquence contenir des détails sur des produits ou informations qui ne sont pas accessibles ou valides dans votre pays.
Merci de vous rapprocher de votre représentant Sebia local. Informations à destination des professionnels de santé.
Lire attentivement les instructions figurant dans les notices et manuels des instruments et réactifs.