About
The monitoring of vitamin D is helpful in diseases where calcium and phosphorus homeostasis or bone metabolism are altered. In children, severe deficiency leads to bone-malformation, known as rickets. Milder degrees of insufficiency are believed to cause reduced efficiency in the utilization of dietary calcium. Vitamin D deficiency causes muscle weakness; in elderly, the risk of falling has been attributed to the effect of vitamin D on muscle function. The two most important forms of vitamin D are vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol). In contrast to vitamin D3, the human body cannot produce vitamin D2, which is taken up with fortified food or given by supplements. It is commonly agreed that 25‑hydroxyvitamin D (25-OH) is the metabolite to determine the overall vitamin D status as it is the major storage form of vitamin D in the human body.
Diagnosis
An early diagnosis of the vitamin D level and its strict monitoring may prevent worsening of bone related conditions.
Sebia’s Expertise
Sebia offers a reliable solution for the measurement of the concentration of 25-(OH)-Vitamin D2 and 25-(OH)-Vitamin D3 with Alegria Monotest random access solution and open-system ELISA testing for a high throughput approach. Sebia´s superior antigen coating procedure and the economical all-in-one Alegria system, bring a unique flexibility for optimal workflow efficiency.
The all-in-one Alegria Monotest is particularly suited for small series and offers unique flexibility for maximum workflow efficiency with the Alegria 2 system.
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Vitamin D
Accurate and reliable Vitamin D level measurements.
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- Steingrimsdottir L, Gunnarsson O, Indridason OS, Franzson L, Sigurdsson G. Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. JAMA. 2005 Nov 9;294(18):2336-41. doi: 10.1001/jama.294.18.2336. PMID: 16278362.
- Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. doi: 10.1056/NEJMra070553. PMID: 17634462.
- Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. doi: 10.1093/ajcn/84.4.694. PMID: 17023693.
- Bosworth CR, Levin G, Robinson-Cohen C, Hoofnagle AN, Ruzinski J, Young B, Schwartz SM, Himmelfarb J, Kestenbaum B, de Boer IH. The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease. Kidney Int. 2012 Sep;82(6):693-700. doi: 10.1038/ki.2012.193. Epub 2012 May 30. PMID: 22648296; PMCID: PMC3434313.
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