A study was performed by Memorial Sloan Kettering Cancer Center on the HYDRASHIFT daratumumab in vitro (IVD) diagnostic assay to provide the clinical community with better tools to monitor patients with multiple myeloma in line with the International Myeloma Group’s (IMWG) latest recommendations.
This assay, intended to be used with HYDRAGEL IF, mitigates the daratumumab mediated interference seen in immunofixation results for patients treated with DARZALEX®, a fully human monoclonal antibody that binds to CD38.
The benefit of HYDRASHIFT has been highlighted in several scientific publications, such as the Journal of Applied Laboratory Medicine (JALM) by AACC by Daniel C Kirchhoff et al., which shows:
- HYDRASHIFT benefits for myeloma patients who are receiving daratumumab therapy to allow correct interpretation and to enable clinicians to provide optimal medical care.
- The HYDRASHIFT 2/4 daratumumab assay is a useful tool to be used in patients with comigrating daratumumab/IgG-K bands with M-spikes of <.25 g/dL.
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