Autoimmune Liver and Gastric Diseases
A complete solution for the diagnosis of gastric and liver autoimmune diseases.
About Autoimmune Liver and Gastric Diseases
The identification and the discrimination of autoantibodies against parietal cells (APCA), mitochondria (AMA), liver-kidney microsome type 1 (LKM-1) and smooth muscle (ASMA) through IFA techniques, are important pillars of gastric and liver autoimmune diseases diagnosis, ensuring high valuable medical insights in a cost-efficiency manner.
The combination of gastroscopy and determination of specific autoantibodies is needed for the diagnosis of gastric and hepatic autoimmune diseases:
- Anti-parietal cell antibodies (ACPA) are an advantageous tool for screening for autoimmune atrophic gastritis (AAG) and pernicious anemia (PA), which can be detected with Sebia’s AAS Mouse Kidney/Stomach Tissue IFA tests. ELISA-based random access Alegria Monotests for the detection of anti-LKM-1, anti-LC1, anti-SLA and intrinsic factor complete Sebia’s portfolio.
- Anti-mitochondrial antibodies (AMA) are the typical biomarkers of primary biliary cholangitis (PBC), being present in 90–95% of patients. Sebia’s offer comprises IFA slides and Alegria Monotests for AMA-M2, anti-Sp100 and anti-gp210.
- Anti-smooth muscle antibodies (ASMA) are a specific diagnostic marker for Autoimmune Hepatitis Type 1 (AIH-1), being present in almost 70% of the patients. These antibodies can be visualized with Sebia’s IFA products AAS Mouse Kidney/Stomach Tissue.
- Anti-Saccharomyces cerevisiae antibodies (ASCA) immunoassays allow the discrimination between inflammatory bowel disease and Crohn’s disease. Simultaneous detection of IgA and IgG ASCA is highly specific to Crohn’s disease (≈90 %) and rarely found in colitis ulcerosa ulcerative colitis patients. Sebia’s offer comprises Alegria Monotests and ELISA assays for the detection of ASCA.
Key benefits
Complete offer
Comprehensive IFA portfolio completed by Sebia’s ELISA-based random access Monotests for Alegria 2.
Easy screening of IFA slides
Premium tissue sections and homogeneous tissue layer.
Broad portfolio
of ELISA-based random access Monotests for an economical workflow.
Reliable, simplified and automated workflow
using Alegria 2 ELISA-based random access analyzer or IFA processor dIFine® P30 and dIFine® automated microscope.
Sebia's offer
Mouse Liver/Kidney/Stomach Tissue is designed for the qualitative and semi-quantitative detection of antinuclear, mitochondrial (AMA), smooth muscle (ASMA), parietal cell (APCA) and liver-kidney microsome type 1 (LKM-1) antibodies by the indirect fluorescent antibody IFA technique.
The identification and discrimination of AMA, ASMA, APCA and LKM-1 autoantibodies through IFA techniques, are important pillars of gastric and liver autoimmune diseases diagnosis in conjunction with other laboratory and clinical findings.
- IFA – FA3403
Rat Kidney/Stomach Tissue is designed for the qualitative and semi-quantitative detection of antinuclear, mitochondrial, smooth muscle and parietal cell antibodies by the indirect fluorescent antibody IFA technique.
The identification and discrimination of AMA, ASMA, APCA and LKM-1 autoantibodies through IFA techniques, are important pillars of gastric and liver autoimmune diseases diagnosis in conjunction with other laboratory and clinical findings.
- IFA – FA3401
Rat Kidney/Stomach/Liver Tissue is designed for the qualitative and semi-quantitative detection of antinuclear, mitochondrial, smooth muscle and parietal cell antibodies by the indirect fluorescent antibody IFA technique.
The identification and discrimination of AMA, ASMA, APCA and LKM-1 autoantibodies through IFA techniques, are important pillars of gastric and liver autoimmune diseases diagnosis in conjunction with other laboratory and clinical findings.
- IFA – FA3402
AMA-M2 is an immunoassay for the in vitro determination of IgG autoantibodies against mitochondrial M2 subtype antigen in human serum samples.
The test is intended to aid in the diagnosis of primary biliary cholangitis (PBC) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 216
- ELISA – ORG 516
Anti-BPI is an immunoassay for the in vitro determination of IgG autoantibodies against bactericidal permeability-increasing protein (BPI) in human serum samples.
The test is intended to aid in the diagnosis of chronic bowel inflammatory conditions like ulcerative colitis (UC), primary sclerosing cholangitis (PSC) and autoimmune hepatitis (AIH) type 1 in conjunction with other laboratory and clinical findings.
- Alegria – ORG 223
Anti-Cathepsin G is an immunoassay for the in vitro determination of IgG autoantibodies against cathepsin G in human serum samples.
The test is intended to aid in the diagnosis of CTD and other related inflammatory rheumatic disorders in conjunction with other laboratory and clinical findings.
- Alegria – ORG 225
Anti-gp210 is an immunoassay for the in vitro determination of IgG autoantibodies against gp210 in human serum samples.
The test is intended to aid in the diagnosis of primary biliary cholangitis (PBC) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 256
Anti-Intrinsic Factor is an immunoassay for the in vitro determination of IgG autoantibodies against intrinsic factor in human serum samples.
The test is intended to aid in the diagnosis of autoimmune gastritis and pernicious anaemia in conjunction with other laboratory and clinical findings.
- Alegria – ORG 247
- ELISA – ORG 647
Anti-Lactoferrin is an immunoassay for the in vitro determination of IgG autoantibodies against lactoferrin in human serum samples.
The test is intended to aid in the diagnosis of the chronic bowel inflammatory condition ulcerative colitis (UC) and primary sclerosing cholangitis (PSC) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 227
Anti-LC1 is an immunoassay for the in vitro determination of IgG autoantibodies against liver cytosolic antigen-1 (LC1) in human serum samples.
The test is intended to aid in the diagnosis of autoimmune hepatitis (AIH) type 2 in conjunction with other laboratory and clinical findings.
- Alegria – ORG 258
Anti-LKM-1 is an immunoassay for the in vitro determination of IgG autoantibodies against liver-kidney microsomal 1 (LKM-1) in human serum samples.
The test is intended to aid in the diagnosis of autoimmune hepatitis (AIH) type 2 in conjunction with other laboratory and clinical findings.
- Alegria – ORG 253
Anti-Lysozyme is an immunoassay for the in vitro determination of IgG autoantibodies against lysozyme in human serum samples.
The test is intended to aid in the diagnosis of chronic bowel inflammatory conditions like ulcerative colitis (UC) and primary sclerosing cholangitis (PSC) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 226
Anti-Parietal Cell is an immunoassay for the in vitro determination of IgG autoantibodies against alpha- and beta-subunits of the parietal cell H+/K+-ATPase in human serum samples.
The test is intended to aid in the diagnosis of autoimmune gastritis and pernicious anaemia in conjunction with other laboratory and clinical findings.
- Alegria – ORG 231
- ELISA – ORG 531
Anti-SLA is an immunoassay for the in vitro determination of IgG autoantibodies against soluble-liver antigen (SLA) in human serum samples.
The test is intended to aid in the diagnosis of autoimmune hepatitis (AIH) type 1 in conjunction with other laboratory and clinical findings.
- Alegria – ORG 257
Anti-Sp100 is an immunoassay for the in vitro determination of IgG autoantibodies against Sp100 in human serum samples.
The test is intended to aid in the diagnosis of primary biliary cholangitis (PBC) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 254
ASCA immunoassays are used for the in vitro determination of respective antibody isotypes against Saccharomyces cerevisiae (ASCA) in human serum samples.
The tests are intended to aid in the diagnosis of chronic bowel inflammatory conditions (Crohn’s disease) in conjunction with other laboratory and clinical findings.
ASCA IgA
- Alegria – ORG 245A
ASCA IgG
- Alegria – ORG 245G
ASCA IgG/IgA
- ELISA – ORG 545
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