Celiac disease
Unmasking celiac disease, empowering health.
About Celiac disease
Diagnosis of celiac disease typically involves a combination of clinical evaluation, serological tests and histological examination. IgA tissue transglutaminase is the most efficient serological test for the diagnosis of celiac disease. Anti-tTG IgA levels correlate with the degree of intestinal damage and values can fluctuate with disease activity. Anti-tTG tests can be used to support diagnosis in symptomatic individuals, to screen at-risk populations or to monitor diet compliance in patients previously diagnosed with celiac disease.
Antibodies directed against deamidated gliadin protein epitopes (DGP) are excellent markers for serological diagnosis of celiac disease. They bind to epitopes of deamidated gliadin fragments that are relevant for celiac disease pathogenesis. DGPs are formed by the action of tTG on native dietary gliadin.
Key benefits
Complete offer
For the diagnosis of celiac disease including different markers and cost-efficient ELISA-based screens.
Economical, non-invasive diagnostics
Using our screening assays ideal for the efficient testing of large numbers of samples.
Highest sensitivity and specificity
For serodiagnosis of celiac disease using human recombinant tissue transglutaminase.
Sebia's offer
Anti-DGP immunoassays are used for the in vitro determination of antibodies against deamidated gliadin peptide epitopes (DGP) in human serum samples. The Screen enables simultaneous detection of IgA and IgG antibodies.
The tests are intended to aid in the diagnosis of celiac disease in conjunction with other laboratory and clinical findings.
Anti-DGP IgA
- Alegria – ORG 251A
- ELISA – ORG 551A
Anti-DGP IgG
- Alegria – ORG 251G
- ELISA – ORG 551G
Anti-DGP Screen
- Alegria – ORG 251S
Anti-Gliadin immunoassays are used for the in vitro determination of autoantibodies against gliadin in human serum samples.
The tests are intended to aid in the diagnosis of celiac disease in conjunction with other laboratory and clinical findings.
Anti-Gliadin IgA
- Alegria – ORG 234A
- ELISA – ORG 534A
Anti-Gliadin IgG
- Alegria – ORG 234G
- ELISA – ORG 534G
Anti-Tissue-Transglutaminase immunoassays are used for the in vitro determination of autoantibodies isotypes against tissue transglutaminase (tTG) in human serum samples. The Screen enables simultaneous detection of IgA and IgG antibodies.
The tests are intended to aid in the diagnosis of celiac disease (CD) in conjunction with other laboratory and clinical findings.
Anti-Tissue-Transglutaminase IgA
- Alegria – ORG 240A
- ELISA – ORG 540A
Anti-Tissue-Transglutaminase IgG
- Alegria – ORG 240G
- ELISA – ORG 540G
Anti-Tissue-Transglutaminase Screen
- Alegria – ORG 240S
- ELISA – ORG 540AS
Alegria-Check Celiac A and Alegria-Check Celiac G are multi-parameter-specific serum controls for daily internal quality control for the respective antibody isotype.
Alegria-Check Celiac A
- Alegria – ORG 170-2X05
Alegria-Check Celiac A is validated for the following assay:
- Anti-Tissue Transglutaminase IgA – ORG 240A
Alegria-Check Celiac G
- Alegria – ORG 169-2X05
Alegria-Check Celiac G is validated for the following assay:
- Anti-Tissue Transglutaminase IgG – ORG 240G
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