Rheumatoid Arthritis
A holistic portfolio with Anti-MCV to unlock the full potential of early diagnosis.
About Rheumatoid Arthritis
Rheumatoid arthritis (RA) is the most common inflammatory musculoskeletal disease affecting 0.5% to 1% of the population. It should be diagnosed ideally 6 weeks to 3 months after onset of RA symptoms to avoid irreversible damage.
Autoantibodies against citrullinated peptides/proteins (ACPA), e.g. anti-MCV, anti-CCP and rheumatoid factor (RF) are essential components of the last ACR/EULAR criteria for classification of RA. Anti-MCV can detect the disease at a very early stage, even in patients who test negative for anti-CCP and to some degree even before the appearance of specific clinical symptoms.
Key benefits
Improved RA diagnosis
Anti-MCV antibodies detection in anti-CCP seronegative patients.
Anti-MCV
An assay based on the citrullinated vimentin, an antigen involved in pathogenesis of RA.
Early detection
Reliable early detection of RA supports rapid selection and implementation of treatment.
Proven medical value
Of anti-MCV by hundreds of publications highlighting increased sensitivity, correlation with disease activity, predictive value.
Sebia's offer
Anti-CCP hs (high sensitive) is an immunoassay for the in vitro determination of IgG autoantibodies against cyclic citrullinated peptides (CCP) in human serum samples.
The test is intended to aid in the diagnosis of rheumatoid arthritis (RA) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 301
- ELISA – ORG 601
Anti-MCV is an immunoassay for the in vitro determination of IgG autoantibodies against mutated citrullinated vimentin (MCV) in human serum samples.
The test is intended to aid in the diagnosis of RA in conjunction with other laboratory and clinical findings.
- Alegria – ORG 248
- ELISA – ORG 548
Rheumatoid Factor immunoassays are used for the in vitro determination of rheumatoid factor antibodies in human serum samples.
The tests are intended to aid in the diagnosis of RA in conjunction with other laboratory and clinical findings.
Rheumatoid Factor IgA
- Alegria – ORG 222A
- ELISA – ORG 522A
Rheumatoid Factor IgG
- Alegria – ORG 222G
- ELISA – ORG 522G
Rheumatoid Factor IgM
- Alegria – ORG 222M
- ELISA – ORG 522M
ANA HEp-2 is an indirect immunofluorescence assay for the qualitative detection and semi-quantitative determination of IgG anti-nuclear antibodies (ANA) in human serum by manual fluorescence microscopy or with the dIFine® automated microscope.
The presence of ANA can be used in conjunction with other serological tests and clinical findings to aid in the diagnosis of systemic lupus erythematosus SLE and other CTD.
- IFA – FA2500A
dsDNA (Crithidia l.) is designed for the qualitative and semi-quantitative detection of antibodies to native DNA by the Indirect Fluorescent Antibody (IFA) technique and is for in vitro diagnostic use.
The anti-dsDNA antibodies have an important role in the development of Systemic Lupus Erythematosus (SLE) disease, and their affordable identification helps in the diagnostic path of this autoimmune condition.
- IFA – FA1001
Alegria – Check Rheuma
- Alegria – ORG 164-2X05
Alegria-Check Rheuma is a multi-parameter-specific serum control for daily internal quality control validated for these assays:
- Rheumatoid Factor IgA – ORG 222A
- Rheumatoid Factor IgM – ORG 222M
- Anti-CCP hs – ORG 301
Featured instruments for Rheumatoid Arthritis
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Related resources
See all resourcesUnlocking the power of anti-MCV detection for early diagnosis of Rheumatoid Arthritis
Educational Webinar with Holger Bang, PhD & Roberto Fiorillo
Alegria 2 properties and workflow
Obtain your patients results with high flexibility reliability and efficiency with Alegria 2.
Customer Testimonial about the Alegria 2
The Alegria 2 provides the possibility of giving results to clinicians within a timeframe fitting clinical needs and helps to optimize the patient’s care pathway.
Scientific publications
See all publicationsAnti-MCV – Fill the gap in rheumatoid arthritis diagnosis
This comprehensive meta-analysis highlights the benefit of testing anti-MCV additionally to anti-CCP and RF in the context of early diagnosis of Rheumatoid Arthritis.
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