Thyroid Diseases
Accuracy in thyroid autoimmune disease diagnostics.
About Thyroid Diseases
The protein thyroglobulin is responsible for the production and storage of thyroid hormones and is a strong autoantigen. High titers of IgG antibodies against thyroglobulin found in conjunction with antibodies against thyroid peroxidase (anti-TPO) are markers for Hashimoto-type chronic autoimmune thyroiditis (Hashimoto’s disease). Thyroglobulin antibodies are found in 50-60 % of patients with this condition.
TPO is important for the production of thyroid hormones. It regulates the oxidative iodination of the tyrosine residues in thyroglobulin. If TPO is inhibited by binding of specific antibodies, less thyroid hormone is produced, which leads to hypothyroidism. Because of the close functional relationship between the two enzymes, antibodies against TPO and thyroglobulin are often found together.
Elevated TPO antibody titers are found in 90 % of patients with autoimmune thyroid disease (Hashimoto’s thyroiditis). TPO antibodies can also be detected in patients with autoimmune hyperthyroidism (Grave’s disease). In some cases, trace concentrations of TPO antibodies are found in healthy individuals, particularly those of advanced age.
Key benefits
Alegria Monotests
For fully automated random-access determination of antibodies against thyroid peroxidase and thyroglobulin.
Sensitive IgG detection
By use of thyroid peroxidase and thyroglobulin purified from human thyroid.
Quantitative determination
of IgG antibodies.
Accurate calibration
With international WHO standards.
Sebia's offer
Anti-TG is an immunoassay for the in vitro determination of IgG autoantibodies against thyroglobulin (TG) in human serum samples. The test is intended to aid in the diagnosis of the autoimmune thyroid diseases Hashimoto’s thyroiditis or Graves’ disease in conjunction with other laboratory and clinical findings.
- Alegria – ORG 202
- ELISA – ORG 502
Anti-TPO is an immunoassay for the in vitro determination of IgG autoantibodies against thyroperoxidase (TPO) in human serum samples. The test is intended to aid in the diagnosis of the autoimmune thyroid diseases Hashimoto’s thyroiditis or Graves’ disease in conjunction with other laboratory and clinical findings.
- Alegria – ORG 203
- ELISA – ORG 503
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