About Vasculitis
Vasculitis are often serious and sometimes fatal diseases requiring prompt recognition and therapy. Reacting rapidly can be key to save a patient’s life.
The detection of Anti-Neutrophil Cytoplasmic Antibodies (ANCA) by immunofluorescence assay (IFA) is the basis of modern diagnosis of ANCA-associated vasculitis. Depending on the pattern, identification and confirmation via IFA or the differentiation through autoantibody-specific immunoassays follow the screening step. High-quality ELISA test systems for the detection of PR3 and MPO antibodies are essential for the serological evidence and monitoring of granulomatosis with polyangiitis (GPA, previously known as Wegener’s granulomatosis), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA) and rapidly progressing glomerulonephritis.
GBM disease (Goodpasture syndrome) can elicit symptoms very similar to those of ANCA-associated vasculitis. Diagnostic indicators of GBM disease are antibodies against the glomerular basement membrane (GBM).
These life-threatening diseases frequently require immediate and aggressive treatment. Only high-performance ELISA test systems with maximum diagnostic sensitivity and specificity provide certainty in diagnosing the disease and considering treatment options.
In addition, the detection of pANCA plays a critical role in the differential diagnosis of Crohn’s disease and ulcerative colitis. Sebia’s offer comprises ANCA IFA test and ELISA-based random access Monotests for a reliable detection of specific antibodies in the context of ANCA-associated vasculits.
Key benefits
Anti-PR3hs
Anchor-ELISA-based random-access assay with an outstanding sensitivity of > 95%.
High specificity
Highly purified human MPO, free of elastase and lactoferrin, avoiding antibodies cross-linking.
Emergency parameter anti-GBM
Can be run with priority.
Uniquely comprehensive product portfolio
offering a wide range of tests, including ANCA and x-ANCA Monotests on Alegria 2 random access test system.
Sebia's offer
ANCAscreen hs (high sensitive) is an immunoassay for the in vitro determination of IgG autoantibodies against proteinase 3 (PR3) and myeloperoxidase (MPO) in human serum samples.
The test is intended to aid in the diagnosis of systemic inflammatory ANCA-associated vasculitis, especially granulomatosis with polyangiitis (GPA) and and eosinophilic granulomatosis with polyangiitis (EGPA) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 389
- ELISA – ORG 689
Anti-BPI is an immunoassay for the in vitro determination of IgG autoantibodies against bactericidal permeability-increasing protein (BPI) in human serum samples.
The test is intended to aid in the diagnosis of ANCA-associated vasculitis in conjunction with other laboratory and clinical findings.
- Alegria – ORG 223
Anti-Cathepsin G is an immunoassay for the in vitro determination of IgG autoantibodies against cathepsin G in human serum samples.
The test is intended to aid in the diagnosis of CTD and other related inflammatory rheumatic disorders in conjunction with other laboratory and clinical findings.
- Alegria – ORG 225
Anti-GBM is an immunoassay for the in vitro determination of IgG autoantibodies against glomerular basement membrane (GBM) in human serum samples.
The test is intended to aid in the diagnosis of Glomerular basement disease (Goodpasture’s syndrome) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 250
- ELISA – ORG 550
Lactoferrin is an immunoassay for the in vitro determination of IgG autoantibodies against lactoferrin in human serum samples.
The test is intended to aid in the diagnosis of the chronic bowel inflammatory condition ulcerative colitis (UC) and primary sclerosing cholangitis (PSC) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 227
Anti-Lysozyme is an immunoassay for the in vitro determination of IgG autoantibodies against lysozyme in human serum samples.
The test is intended to aid in the diagnosis of chronic bowel inflammatory conditions like ulcerative colitis (UC) and primary sclerosing cholangitis (PSC) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 226
Anti-MPO (pANCA) is an immunoassay for the in vitro determination of IgG autoantibodies against myeloperoxidase (MPO) in human serum samples.
The test is intended to aid in the diagnosis of systemic inflammatory ANCA (antineutrophil cytoplasmic autoantibodies) associated vasculitis, especially eosinophilic granulomatosis with polyangiitis (EGPA) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 219
- ELISA – ORG 519
Anti-PR3 hs is an immunoassay for the in vitro determination of IgG autoantibodies against proteinase 3 (PR3) in human serum samples.
The test is intended to aid in the diagnosis of systemic inflammatory ANCA (antineutrophil cytoplasmic autoantibodies) associated vasculitis, especially granulomatosis with polyangiitis (GPA) in conjunction with other laboratory and clinical findings.
- Alegria – ORG 318
- ELISA – ORG 618
Alegria – Check Vasculitis
- Alegria – ORG 167-2X05
Alegria-Check Vasculitis is a multi-parameter-specific serum control for daily internal quality control validated for the following assays:
- Anti-MPO – ORG 219
- Anti-PR3 – ORG 218
- Anti-PR3 hs – ORG 318
- Anti-GBM – ORG 250
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